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Butalbital and Acetaminophen Description
Butalbital and Acetaminophen is supplied in tablet form for oral administration.
Butalbital (5-allyl-5-isobutylbarbituric acid), a slightly bitter, white, odorless, crystalline powder, is a short to intermediate-acting barbiturate. It has the following structural formula:
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Butalbital and Acetaminophen is supplied in tablet form for oral administration.
Butalbital (5-allyl-5-isobutylbarbituric acid), a slightly bitter, white, odorless, crystalline powder, is a short to intermediate-acting barbiturate. It has the following structural formula:
Acetaminophen (4กฏ-hydroxyacetanilide), a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:

Butalbital/APAP/Caffeine Oral Side Effects
Nausea, vomiting, abdominal pain, shaking (tremor), shortness of breath, lightheadedness, dizziness, or drowsiness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur:
- mental/mood changes
- fainting
- seizure
- fast/irregular heartbeat
- increased thirst/urination
Tell your doctor immediately if any of these rare but very serious side effects occur:
- signs of infection (e.g., fever, persistent sore throat)
- easy bruising/bleeding
- change in the amount of urine
If you do not have liver problems, the adult maximum dose of acetaminophen is 4 grams per day (4000 milligrams). If you take more than the maximum daily amount, it may cause serious (possibly fatal) liver disease. Tell your doctor immediately if you have any of the following symptoms of liver damage:
- persistent nausea/vomiting
- yellowing eyes/skin
- dark urine
- severe stomach/abdominal pain
- extreme tiredness
A very serious allergic reaction to butalbital is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:
- rash
- itching
- swelling
- severe dizziness
- trouble breathing
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